Hoʻonui i ka mālama ʻana i ka mea maʻi me ka hoʻoponopono ʻana i ka Attenuation AI-Based ma PET Imaging

Ua paʻi ʻia nei kahi noiʻi hou i kapa ʻia ʻo "Utilizing Pix-2-Pix GAN for Deep Learning-Based Whole-Body PSMA PET/CT Attenuation Correction" ma ka Volume 15 o Oncotarget ma Mei 7, 2024.

He mea hopohopo ka hōʻike ʻana o ka radiation mai nā haʻawina PET/CT maʻamau i ka hahai ʻana o nā mea maʻi oncology. Ma kēia noiʻi hou, ua hoʻolauna kahi hui o nā mea noiʻi e like me Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, a me Stephanie A. Harmon mai ka National Cancer Institute ma ka National Institutes of Health i kahi mea hana akamai artificial (AI). ʻO ka pahuhopu o kēia mea hana ke hana i nā kiʻi PET attenuation-corrected (AC-PET) mai nā kiʻi PET non-attenuation-corrected (NAC-PET), e hōʻemi ana paha i ka pono no nā scan CT haʻahaʻa.

"Loaʻa i nā kiʻi PET i hana ʻia e Ai ka hiki ke hōʻemi i ka pono no ka hoʻoponopono ʻana i ka attenuation ma nā scan CT ʻoiai e mālama ana i nā māka quantitative a me ka maikaʻi o ke kiʻi no nā maʻi maʻi prostate."

Nā Hana: Ua hoʻomohala ʻia kahi algorithm aʻo hohonu e pili ana i ka 2D Pix-2-Pix generative adversarial network (GAN) architecture ma muli o nā kiʻi AC-PET a me NAC-PET i hui pū ʻia. Ua māhele ʻia ke aʻo ʻana o 18F-DCFPyL PSMA (Prostate-specific membrane antigen) PET-CT o 302 mau maʻi me ka maʻi prostate i nā hui hoʻomaʻamaʻa, hōʻoia, a me nā hoʻāʻo (n 183, 60, a me 59, kēlā me kēia). Ua hoʻomaʻamaʻa ʻia ke kumu hoʻohālike me ka hoʻohana ʻana i ʻelua mau hoʻolālā maʻamau: Standard Uptake Value (SUV) ma muli o SUV-NYUL. Ua loiloi ʻia ka hana pae scanning me ka hoʻohana ʻana i ka normalized mean square error (NMSE), mean absolute error (MAE), structural similarity index (SSIM) a me ka peak signal-to-noise ratio (PSNR). Ua hana mua ke kauka lāʻau lapaʻau nuklea i kahi loiloi pae lesion o ka wahi hoihoi. Ua loiloi ʻia nā ʻōkuhi SUV me ka hoʻohana ʻana i ka intra-group correlation coefficient (ICC), repeatability coefficient (RC), a me nā linear mixed effects models.

Nā Hualoaʻa：I loko o ka hui hoʻāʻo kūʻokoʻa, ʻo ka awelika NMSE, MAE, SSIM, a me PSNR he 13.26%, 3.59%, 0.891, a me 26.82, kēlā me kēia. ʻO ka ICC no SUVmax a me SUVmean he 0.88 a me 0.89, e hōʻike ana i kahi pilina ikaika ma waena o nā māka kiʻi quantitative mua a me nā mea i hana ʻia e AI. Ua ʻike ʻia nā mea e like me ka wahi o ka lesion, ka density (nā ʻāpana Hounsfield), a me ka lesion uptake e hoʻopilikia i ka hewa pili i nā metric SUV i hana ʻia (ʻo nā p < 0.05 āpau).

"Hōʻike ka AC-PET i hana ʻia e ke kumu hoʻohālike Pix-2-Pix GAN i nā ana SUV e pili pono ana me nā kiʻi kumu. Hōʻike nā kiʻi PET i hana ʻia e AI i ka hiki ke hoʻohiki lapaʻau no ka hōʻemi ʻana i ka pono o nā scan CT no ka hoʻoponopono ʻana i ka attenuation ʻoiai e mālama ana i nā māka quantitative a me ka maikaʻi o ke kiʻi."

——————————————————————————————————————————————————————————————————————————————————————————–

E like me kā kākou e ʻike nei, ʻo ka hoʻomohala ʻana o ka ʻoihana kiʻi lapaʻau he mea hiki ʻole ke hoʻokaʻawale ʻia mai ka hoʻomohala ʻana o kahi moʻo o nā lako lapaʻau - nā mea hoʻokomo ʻākena hoʻohālikelike a me kā lākou mau mea hoʻopau kākoʻo - i hoʻohana nui ʻia ma kēia kahua. Ma Kina, kahi i kaulana no kāna ʻoihana hana, he nui nā mea hana kaulana ma ka home a ma waho no ka hana ʻana i nā lako kiʻi lapaʻau, meʻO LnkMedMai kona hoʻokumu ʻia ʻana, ua kālele nui ʻo LnkMed i ke kahua o nā mea hoʻokomo ʻokoʻa kiʻekiʻe. Ke alakaʻi ʻia nei ka hui ʻenekinia o LnkMed e kahi Ph.D. me nā makahiki he ʻumi a ʻoi aku o ka ʻike a ua komo nui ʻo ia i ka noiʻi a me ka hoʻomohala ʻana. Ma lalo o kāna alakaʻi ʻana, ʻo kaʻO ka mea hoʻokomo poʻo hoʻokahi CT,ʻO ka mea hoʻokomo poʻo pālua CT,Mea hoʻokomo ʻokoʻa MRI, a meʻO ka mea hoʻokomo ʻokoʻa kiʻekiʻe o ke kaomi angiographyua hoʻolālā ʻia me kēia mau hiʻohiʻona: ke kino ikaika a paʻa, ka ʻaoʻao hana maʻalahi a akamai, nā hana piha, palekana kiʻekiʻe, a me ka hoʻolālā paʻa. Hiki iā mākou ke hāʻawi i nā syringes a me nā paipu e kūpono me kēlā mau lama kaulana o CT, MRI, DSA injectors Me ko lākou ʻano ʻoiaʻiʻo a me ka ikaika ʻoihana, ke kono aku nei nā limahana āpau o LnkMed iā ʻoe e hele mai e ʻimi pū i nā mākeke hou aʻe.